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Philine Wangemann Selected Research

Pendred syndrome

5/2013SLC26A4 mutation testing for hearing loss associated with enlargement of the vestibular aqueduct.
1/2011SLC26A4 genotypes and phenotypes associated with enlargement of the vestibular aqueduct.
1/2008Free radical stress-mediated loss of Kcnj10 protein expression in stria vascularis contributes to deafness in Pendred syndrome mouse model.
5/2007Lack of pendrin HCO3- transport elevates vestibular endolymphatic [Ca2+] by inhibition of acid-sensitive TRPV5 and TRPV6 channels.
5/2007Loss of cochlear HCO3- secretion causes deafness via endolymphatic acidification and inhibition of Ca2+ reabsorption in a Pendred syndrome mouse model.
12/2006Macrophage invasion contributes to degeneration of stria vascularis in Pendred syndrome mouse model.
8/2004Loss of KCNJ10 protein expression abolishes endocochlear potential and causes deafness in Pendred syndrome mouse model.

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Philine Wangemann Research Topics

Disease

8Deafness (Deaf Mutism)
03/2011 - 07/2002
7Pendred syndrome
05/2013 - 08/2004
4Goiter
05/2013 - 12/2006
4Hearing Loss (Hearing Impairment)
05/2013 - 10/2007
3Sudden Hearing Loss (Sudden Deafness)
11/2010 - 12/2002
2Nonsyndromic Deafness
02/2015 - 07/2002
2Sensorineural Hearing Loss
01/2011 - 11/2005
2Ischemic Stroke
11/2005 - 12/2002
1Pulmonary Hypertension
09/2015
1Autosomal Recessive 49 Deafness
02/2015
1Autosomal Recessive 42 Deafness
02/2015
1Inborn Genetic Diseases (Disease, Hereditary)
10/2009
1Inflammation (Inflammations)
12/2006
1Meniere Disease (Menieres Disease)
06/2004

Drug/Important Bio-Agent (IBA)

3Phenobarbital (Luminal)FDA Link
03/2011 - 06/2004
3ConnexinsIBA
10/2007 - 07/2002
2Proteins (Proteins, Gene)FDA Link
01/2008 - 08/2004
2AnionsIBA
05/2007 - 12/2006
2rho-Associated KinasesIBA
11/2005 - 12/2002
1Terpenes (Terpenoids)IBA
09/2015
1MARVEL Domain Containing 2 ProteinIBA
02/2015
1IodidesIBA
05/2013
1Doxycycline (Periostat)FDA LinkGeneric
11/2011
1IodineIBA
01/2011
1sphingosine 1-phosphate (sphingosine-1-phosphate)IBA
11/2010
1Etanercept (Enbrel)FDA Link
11/2010
1Prednisolone (Predate)FDA LinkGeneric
11/2010
1Tumor Necrosis Factor-alpha (Tumor Necrosis Factor)IBA
11/2010
1PotassiumIBA
10/2009
1Ethylnitrosourea (N-Ethyl-N-nitrosourea)IBA
08/2009
1Free RadicalsIBA
01/2008
1Member 2 Solute Carrier Family 12IBA
10/2007
1K Cl- CotransportersIBA
10/2007
1Proton-Translocating ATPases (ATPase, H+)IBA
10/2007
1Interleukin-6 (Interleukin 6)IBA
12/2006
1Endothelin-1 (Endothelin 1)IBA
11/2005
1GlucocorticoidsIBA
06/2004
1cyclo(Trp-Asp-Pro-Val-Leu)IBA
12/2002
1Y 27632IBA
12/2002
15- (dimethylamino)- N- (3,4- dimethyl- 5- isoxazolyl)- 1- naphthalenesulfonamideIBA
12/2002